TMP780 是一种 RORγt 反向激动剂，IC50 值为 13 nM。RORγt 是皮肤炎症性疾病研究的优良靶点。
货号:ajcx33884
CAS:1422053-03-9
分子式:C31H30N2O4
分子量：494.58
溶解度:DMSO : 220 mg/mL (444.82 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TMP780 is an inverse agonist of RORγt with an IC50 of 13 nM. RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders[1].

[1]. Skepner J, et al. Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo. J Immunol. 2014 Mar 15;192(6):2564-75.