TP0586532 是 non-hydroxamate LpxC 抑制剂 (IC50=0.101 μM)。TP0586532 作为一种低心血管风险的化合物，对肺炎克雷伯菌有效，包括耐药菌株。
货号:ajcx35870
CAS:2427584-96-9
分子式:C26H28N4O4
分子量：460.52
溶解度:DMSO : 50 mg/mL (108.57 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TP0586532 is a non-hydroxamate LpxC inhibitor (IC50=0.101 μM). TP0586532 as a compound with a low cardiovascular risk that is effective against K. pneumoniae, including resistant strains[1].

TP0586532 as a compound with a low cardiovascular risk that is effective against K. pneumoniae, including resistant strains[1].

[1]. Ushiyama F, et al. Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532. Bioorg Med Chem. 2021;30:115964.