Zenarestat 是一种有效的、具有口服活性的醛糖还原酶 (aldose reductase) 抑制剂。Zenarestat 改善 Zucker 糖尿病脂肪大鼠的糖尿病周围神经病变。
货号:ajcx36756
CAS:112733-06-9
分子式:C17H11BrClFN2O4
分子量：441.64
溶解度:DMSO : 100 mg/mL (226.43 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Zenarestat is a potent and orally active aldose reductase inhibitor. Zenarestat improves diabetic peripheral neuropathy in Zucker diabetic fatty rats[1].

Zenarestat (3.2, 32 mg/kg; p.o.; daily for 8 weeks) inhibits nerve sorbitol accumulation in a dose-dependent manner[1].

[1]. Shimoshige Y, et al. The effects of zenarestat, an aldose reductase inhibitor, on peripheral neuropathy in Zucker diabetic fatty rats. Metabolism. 2000;49(11):1395-1399.