I-191 是一种有效选择性的蛋白酶激活受体 2 (PAR2) 拮抗剂。
货号:ajcx38674
CAS:1690172-25-8
分子式:C23H26FN5O2
分子量：423.48
溶解度:DMSO : 8.33 mg/mL (19.67 mM; Need ultrasonic)|H2O :< 0.1 mg/mL (insoluble)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist[1].

I-191 inhibits cytokine production as well as cytokine-related caspase cleavages via ERK1/2 signaling in HT29 colon cancer cells[1].

[1]. Jiang Y, et al. A Potent Antagonist of Protease-Activated Receptor 2 That Inhibits Multiple Signaling Functions in Human Cancer Cells. J Pharmacol Exp Ther. 2018 Feb;364(2):246-257.