AF40431 是首个报道的 sortilin 小分子配体，IC50 为 4.4 µM，Kd 为 0.7 µM。AF40431 结合在 sortilin 的神经降压素结合位点。
货号:ajcx15014
CAS:181125-92-8
分子式:C17H21NO5
分子量：319.35
溶解度:DMSO: 25 mg/mL (78.28 mM; ultrasonic and adjust pH to 1 with TFA)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AF40431, the first reported small-molecule ligand of sortilin, has an IC50 of 4.4 µM and a Kd of 0.7 µM . AF40431 is bound in the neurotensin-binding site of sortilin[1].

[1]. Andersen JL, et al. Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex. Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):451-60.