JWG-071 是首次报道的 ERK5 激酶选择性化学探针。JWG-071 提高了 ERK5 活性和 BRD4 选择性。JWG-071 将是反卷积 ERK5 和 BRD4 药理学急需的化学探针。
货号:ajcx15392
CAS:2250323-50-1
分子式:C34H44N8O3
分子量：612.76
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

JWG-071 is the first reported kinase-selective chemical probe for ERK5. JWG-071 improves ERK5 activity and BRD4 selectivity. JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology[1].

JWG-071 inhibits ERK5 and LRRK2 with IC50 of 88 and 109 nM, respectively[1].

[1]. Wang J, et al. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinonesas Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448