ML401 是一种有效的化学探针，选择性地拮抗 EBI2 (也称为 GPR183)，IC50 值为1.03 nM。ML401 在趋化性分析中显示活性 (IC50=6.24 nM)。ML401 表现出良好的稳定性，且无细胞毒性。
货号:ajcx15424
CAS:1597489-14-9
分子式:C20H20BrClN2O
分子量：419.74
溶解度:DMSO: 10.42 mg/mL (24.82 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity[1].

ML401 shows no toxicity (>50 μM) towards immortalized Fa2-N4 human hepatocytes and non-cytotoxic in MTT in both LnCap and IMR-32 cells (>50 μM)[1].

ML401 shows very good stability in both human plasma and mouse plasma[1].

[1]. Ardecky R, et al. Functional Antagonists of EBI-2. Probe Reports from the NIH Molecular Libraries Program [Internet].