S26131 (compound 5) 是一种高效、选择性的 MT1 褪黑激素配体。对 MT1 和 MT2 的 Ki 值分别为 0.5 和 112 nM。S26131 表现为 MT1 和 MT2 拮抗剂。
货号:ajcx15472
CAS:296280-56-3
分子式:C31H34N2O4
分子量：498.61
溶解度:DMSO: 5 mg/mL (10.03 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

S26131 (compound 5) is a potent and selective MT1 melatoninergic ligand, and the Ki values are 0.5 and 112 nM for MT1 and MT2, respectively. S26131 behaves as an MT1 and MT2 antagonist[1].

S26131 behaves as an antagonist on MT1 and MT2 receptors with KB values of 5.32 and 143 nM, respectively[1].

[1]. Descamps-FranÇois C, et al. Design and synthesis of naphthalenic dimers as selective MT1 melatoninergic ligands. J Med Chem. 2003 Mar 27;46(7):1127-9.