Autotaxin-IN-3 是 Autotaxin(ATX) 抑制剂，IC50 值为 2.4 nM，源于专利 WO2018212534A1 中，化合物 33。
货号:ajcx15564
CAS:2156655-68-2
分子式:C22H21N9O2
分子量：443.46
溶解度:DMSO: 250 mg/mL (563.75 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Autotaxin-IN-3 is a Autotaxin(ATX) inhibitor with an IC50 of 2.4 nM, compound 33, sourced from patent WO2018212534A1[1].

Autotaxin is an enzyme which is responsible for the increase in lysophosphatidic acid in ascites and plasma, and it is a secretory enzyme important for converting lysophosphatidylchloine (LPC) into lysophosphatidic acid (LPA) as a bioactive signaling molecule[1].

[1]. LEE, Dae Yon, et al. NOVEL COMPOUNDS AS AUTOTAXIN INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME. Patent O2018212534A1