DC-5163 是一种有效的 3-磷酸甘油醛脱氢酶 (GAPDH) 抑制剂，IC50 为 176.3 nM，Kd 为 3.192 μM。DC-5163 可部分抑制糖酵解途径，还选择性抑制癌细胞增殖并诱导凋亡 (apoptosis)。
货号:ajcx16500
CAS:897771-47-0
分子式:C18H20ClN3OS
分子量：361.89
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

DC-5163 is a potent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor with an IC50 of 176.3 nM and a Kd of 3.192 μM. DC-5163 can inhibit glycolysis pathway partially. DC-5163 also selectively inhibits cancer cell proliferation and induces apoptosis[1].

[1]. Li T, et al. Discovery of novel glyceraldehyde-3-phosphate dehydrogenase inhibitor via docking-based virtual screening. Bioorg Chem. 2020 Mar;96:103620.