Gemcitabine-O-Si(di-iso)-O-Mc是抗体偶联药物的一部分，由嘧啶核苷类似物抗代谢药和抗肿瘤剂Gemcitabine和ADClinker连接而成。
货号:ajcx30708
CAS:N/A
分子式:C24H36F2N4O7Si
分子量：558.65
溶解度:DMSO: 100 mg/mL (179.00 mM); H2O:< 0.1 mg/mL (insoluble)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Gemcitabine-O-Si(di-iso)-O-Mc is a drug-linker conjugate for ADC with potent antitumor activity by using Gemcitabine (a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent;), linked via the ADC linker[1].

Antibody drug conjugates (ADC) couple therapeutic monoclonal antibodies (mAb) with potent toxins through a linker that is stable within systemic circulation, but cleaves within the target cells[1].

[1]. Mathew C. Finniss, et al. A versatile acid-labile linker for antibody-drug conjugate. MedChemComm, Issue 9, 2014.