Terevalefim (ANG-3777) 是一种干细胞生长因子 (HGF) 的类似物，选择性的激活 c-Met 受体。
货号:ajcx35244
CAS:1070881-42-3
分子式:C9H8N2S
分子量：176.24
溶解度:DMSO : 100 mg/mL (567.41 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor[1][2].

Terevalefim (ANG-3777) (0-10 μM) significantly inhibited cancer cells proliferation in HUVECs[2].

Terevalefim (ANG-3777) decreases apoptosis, increases proliferation, and promotes organ repair and function in animal models[1].Terevalefim (ANG-3777, 40 mg/kg, IP) phosphorylates the c-Met receptor in rats[2].

[1]. Jonathan S Bromberg, et al. Renal Function Improvement Following ANG-3777 Treatment in Patients at High Risk for Delayed Graft Function After Kidney Transplantation. Transplantation. 2021 Feb 1;105(2):443-450.
[2]. Latha Paka, et al. The Effect of ANG-3777 on Hepatocyte Growth Factor Receptor, c-MET Signaling. American Transplant Society.