E3ligaseLigand1dihydrochloride是VHLE3连接酶(b>VHLE3ligase)配体，可用于PROTAC技术。
货号:ajcx13318
CAS:N/A
分子式:C23H34Cl2N4O3S
分子量：517.51
溶解度:DMSO : 100 mg/mL (193.23 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

E3 ligase Ligand 1 dihydrochloride is a Hippel-Landau (VHL) E3 ligase-binding moiety based on PROTAC technology.

E3 ligase Ligand 1 dihydrochloride is a Hippel-Landau (VHL) E3 ligase-binding moiety based on PROTAC technology. E3 ligase Ligand 1 is a part of the active BRD4 PROTAC ARV-771, wich is a potent pan-BET degrader with antitumor activity[1].

[1]. Raina K, et al. PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7124-9.