Lenalidomide-propargyl-C2-NH2 hydrochloride 结合了 E3 泛素连接酶的配体 cereblon (CRBN) 和一个连接桥。Lenalidomide-propargyl-C2-NH2 hydrochloride 可用于设计 PROTAC MD-224.
货号:ajcx15400
CAS:N/A
分子式:C18H20ClN3O3
分子量：361.82
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Lenalidomide-propargyl-C2-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. Lenalidomide-propargyl-C2-NH2 hydrochloride can be used to design the PROTAC MD-224 [1].

[1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis TargetingChimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable TumorRegression. J Med Chem. 2019 Jan 24;62(2):448-466.