Sparfosic acid trisodium 是天门冬氨酸氨甲酰转移酶 (aspartate transcarbamoyl transferase) 的有效抑制剂，具有抗肿瘤和抗代谢物活性。天冬氨酸氨甲酰转移酶催化第二步 de novo 嘧啶生物合成。
货号:ajcx17022
CAS:70962-66-2
分子式:C6H7NNa3O8P
分子量：321.06
溶解度:H2O: 250 mg/mL (778.67 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Sparfosic acid trisodium, is a potent inhibitor of aspartate transcarbamoyl transferase, with anti-tumor and antimetabolite activity. Aspartate transcarbamoyl transferase catalyzes the second step of de novo pyrimidine biosynthesis[1][2].

[1]. Wang J, et al. Elevated cyclin A associated kinase activity promotes sensitivity of metastatic human cancer cells to DNA antimetabolite drug. Int J Oncol. 2015 Aug;47(2):782-90. [2]. Angela D. Morris, et al. A New, Efficient, Two Step Procedure for the Preparation of the Antineoplastic Agent Sparfosic Acid