HCoV-229E-IN-1 是 HCoV-229E 复制的有效抑制剂，在 MTS 和 CPE 细胞中的 EC50 值分别为 0.65 μM 和 0.6 μM。
货号:ajcx33676
CAS:N/A
分子式:C38H53N3O2
分子量：583.85
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

HCoV-229E-IN-1 is a potent inhibitor of HCoV-229E replication, with an EC50 of 0.65 μM and 0.6 μM in MTS and CPE cells, respectively[1].

HCoV-229E-IN-1 (compound 5h) (0.01-100 μM) fully suppresses the capacity of HCoV-229E replication in a dose-dependent manner[1].HCoV-229E-IN-1 (12 μM) fully prevented the formation of dsRNA intermediates of CoV RNA synthesis[1].

[1]. Stevaert A, et, al. Betulonic Acid Derivatives Interfering with Human Coronavirus 229E Replication via the nsp15 Endoribonuclease. J Med Chem. 2021 May 13;64(9):5632-5644.