bio-THZ1 是THZ1 的生物素结构，与CDK7 不可逆的结合。THZ1 是有效，选择性的共价 CDK7 抑制剂，IC50 为 3.2 nM。
货号:ajcx34150
CAS:1604811-14-4
分子式:C52H65ClN12O8S
分子量：1053.67
溶解度:DMSO : 120 mg/mL (113.89 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7. THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM[1].

[1]. Kwiatkowski N, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul 31;511(7511):616-20.