TAK-071是一种新型,高效，选择性的毒蕈碱乙酰胆碱受体1(M1R)正变构调节剂。TAK-071激活M1R的EC50为520nM。
货号:ajcx12484
CAS:1820812-16-5
分子式:C24H24FN3O3
分子量：421.46
溶解度:DMSO : 135 mg/mL (320.32 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TAK-071 is a novel muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC50 of TAK-071 M1R agonist activities is 520 nM[1].

[1]. Sako Y, et al. TAK-071, a novel M1 positive allosteric modulator with low cooperativity, improves cognitive function in rodents with few cholinergic side effects. Neuropsychopharmacology. 2018 Aug 1. doi: 10.1038/s41386-018-0168-8.