Balovaptan是一种高效的，选择性的，可透过血脑屏障的后叶加压素1a受体(vasopressin1a(hV1a)receptor)拮抗剂，对人和小鼠(hV1a,mV1a)受体的Ki值分别为1和39nM，可用于自闭症的研究。
货号:ajcx12564
CAS:1228088-30-9
分子式:C22H24ClN5O
分子量：409.91
溶解度:DMSO: 62.5 mg/mL (152.47 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism.

Balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for hV1a and mhV1a, and is used for the research of autism. Balovaptan shows >30000-fold selectivity for hV1a over hV2 receptors, 9891-fold selectivity over hOTR (human oxytocin receptor)[1].

[1]. Ratni H, et al. Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach. J Med Chem. 2015 Mar 12;58(5):2275-89.