JAK1-IN-4是一种有效、选择性的JAK1抑制剂，对JAK1，JAK2和JAK3的IC50值分别为85nM，12.8μM和>30μM。在NCI-H1975细胞中，JAK1-IN-4抑制STAT3的磷酸化，IC50值为227nM。
货号:ajcx12944
CAS:2091134-35-7
分子式:C26H32FN9O2
分子量：521.59
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

JAK1-IN-4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively. JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM)[1].

[1]. Annika Birgitta Margareta ?STRAND, et al. Compounds and methods for inhibiting jak.