BPK-29 hydrochloride 是一种特殊的配体，通过共价修饰 C274 来破坏非典型孤核受体 NR0B1 与 RBM45，SNW1 蛋白质的相互作用。BPK-29 hydrochloride 损害 KEAP1 突变癌细胞的锚定独立生长。
货号:ajcx15110
CAS:2444815-73-8
分子式:C26H33Cl2N3O3
分子量：506.46
溶解度:DMSO: 62.5 mg/mL (123.41 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

BPK-29 hydrochloride is a specific ligand that disrupts the atypical orphan nuclear receptor NR0B1-protein (such RBM45 and SNW1) interactions by covalently modifying C274. BPK-29 hydrochloride impairs the anchorage-independent growth of KEAP1-mutant cancer cells[1].

BPK-29 hydrochloride substantially engages NR0B1 with good overall proteomic selectivity in KEAP1-mutant Non-Small Cell Lung Cancers[1].

[1]. Bar-Peled L, et al. Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. Cell. 2017 Oct 19;171(3):696-709.e23.