Fmoc-Gly-Gly-D-Phe-OtBu 是一种常用的可降解的抗体-药物偶联物 (ADCs) 的连接桥。Fmoc-Gly-Gly-D-Phe-OtBu 是 Fmoc-Gly-Gly-Phe-OtBu 的 R 型对映异构体。
货号:ajcx15610
CAS:N/A
分子式:C32H35N3O6
分子量：557.64
溶解度:DMSO: 100 mg/mL (179.33 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Fmoc-Gly-Gly-D-Phe-OtBu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Gly-Gly-D-Phe-OtBu is the R-isomer of Fmoc-Gly-Gly-Phe-OtBu [1].

[1]. Bak A, et al. Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using an (acyloxy)alkoxy linker. J Pept Res. 1999 Apr;53(4):393-402.