PF-06952229 是一种强效、选择性和口服的 TGFbR1 抑制剂。PF-06952229 与 TGFbR1 特异性结合，阻止 TGFbR1 介导的信号转导。PF-06952229 是一种很有前途的抗肿瘤试剂 (antineoplastic agent)，主要用于研究实体瘤，尤其是转移性乳腺癌。
货号:ajcx17008
CAS:1801333-55-0
分子式:C23H24ClFN4O3
分子量：458.91
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PF-06952229 is a potent, selective and orally active TGFbR1 inhibitor. PF-06952229 specifically binds to TGFbR1 and prevents TGFbR1-mediated signal transduction. PF-06952229 is a promising antineoplastic agent for the study solid tumors, especifically metastatic breast cancer[1].

[1]. Flavia Mercer Pernasetti, et al. Combinations of tgfb inhibitors and cdk inhibitors for the treatment of breast cancer. Patent WO2020058820A1.