CTAPTFA是一种强效、高选择性的脑渗透类阿片受体(μopioidreceptor）拮抗剂(IC50=3.5nM)，对δopioid受体(IC50=4500nM)和生长抑素受体具有超过1200倍的选择性。CTAPTFA可用于L-多巴胺诱导的运动障碍(LID)的研究。
货号:ajcx30444
CAS:N/A
分子式:C53H70F3N13O12S2
分子量：1218.32
溶解度:H2O: 100 mg/mL (82.08 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CTAP TFA is a potent, highly selective, and brain penetrant μ opioid receptor antagonist (IC50=3.5 nM) and displays over 1200-fold selectivity over δ opioid (IC50=4500 nM) and somatostatin receptors. CTAP TFA can be used for the study of L-DOPA-induced dyskinesia (LID)[1].

[1]. Mitchell J Bartlett, et al. Highly-selective µ-opioid Receptor Antagonism Does Not Block L-DOPA-induced Dyskinesia in a Rodent Model.BMC Res Notes