5-Fluoro-2'-deoxycytidine，一种氟嘧啶核苷类似物，是DNA甲基转移酶(DNMT)抑制剂。5-Fluoro-2'-deoxycytidine是有效的胸苷酸合酶抑制剂5-fluoro-2′-dUMP的肿瘤选择性前药。
货号:ajcx32206
CAS:10356-76-0
分子式:C9H12FN3O4
分子量：245.21
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

5-Fluoro-2'-deoxycytidine, a fluoropyrimidine nucleoside analogue, is a DNA methyltransferase (DNMT) inhibitor. 5-Fluoro-2'-deoxycytidine is a tumor-selective prodrug of the potent thymidylate synthase inhibitor 5-fluoro-2′-dUMP[1][2].

[1]. Beumer JH, et, al. Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine in mice. Clin Cancer Res. 2006 Dec 15;12(24):7483-91. [2]. Osterman DG, et, al. 5-Fluorocytosine in DNA is a mechanism-based inhibitor of HhaI methylase. Biochemistry. 1988 Jul 12;27(14):5204-10.