Stafia-1 是一种有效的 STAT5a 的抑制剂 (K i=10.9 μM, IC50=22.2 μM)。Stafia-1 与 STAT5b 和其他 STAT 家族成员相比，显示出高选择性。
货号:ajcx33962
CAS:N/A
分子式:C24H27O10P
分子量：506.44
溶解度:DMSO : 250 mg/mL (493.64 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Stafia-1 is a potent STAT5a inhibitor (K i=10.9 μM, IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members[1].

Stafia-1 shows at least 9-fold selectivity over STAT5b and higher selectivity against other STAT family members[1].

[1]. Natarajan K, et al. Stafia-1: a STAT5a-Selective Inhibitor Developed via Docking-Based Screening of in Silico O-Phosphorylated Fragments. Chemistry. 2020;26(1):148-154.