CL2A 是一种可降解 (cleavable) 的含PEG8-和三偶氮的 PBC-肽-mc linker。CL2A 通过 pH 敏感性降解，产生旁观者效应，并通过二硫键与抗体结合在半胱氨酸残基上。Labetuzumab govitecan 药物使用了这个 linker。
货号:ajcx34628
CAS:2616704-22-2
分子式:C50H79N9O16
分子量：1062.21
溶解度:DMSO : 200 mg/mL (188.29 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CL2A is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker[1].

[1]. Samantha Congreve, et al. Antibody drug conjugates (ADC). Teknisk- naturvetenskaplig fakultet