IGS-1.76 有效抑制人 NCS-1/Ric8a 复合物。IGS-1.76 对 hNCS-1 有很好的的亲和力，且能有效的调节hNCS-1/Ric8a 的相互作用。
货号:ajcx34858
CAS:313480-47-6
分子式:C22H18N2OS
分子量：358.46
溶解度:DMSO : 250 mg/mL (697.43 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

IGS-1.76 efficiently inhibits the human NCS-1/Ric8a complex. IGS-1.76 shows a significantly increased affinity for hNCS-1 and is able to modulate the hNCS-1/Ric8a interaction efficiently[1].

IGS-1.76 is a Drosophila NCS-1/IGS-1.76 complex inhibitor[1].

[1]. Carlos Roca, et al. Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators. J Med Chem. 2018 Jul 26;61(14):5910-5921.