RU-301 是 pan-TAM 受体抑制剂，通过在 TAM 的 Gas6 和 Ig1 结构域之间的界面处结合发挥 pan-TAM 抑制活性，Kd 和 IC50 值分别为 12 μM 和 10 μM。
货号:ajcx15002
CAS:1110873-99-8
分子式:C21H19F3N4O4S
分子量：480.46
溶解度:DMSO: 250 mg/mL (520.33 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

RU-301 is a pan-TAM receptor inhibitor, exerts pan-TAM inhibitory activity by binding at the interface between Gas6 and the Ig1 domain of the respective TAMs with Kd and IC50 values of 12 μM and 10 μM, respectively[1].

[1]. Kimani SG, et al. Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity. Sci Rep. 2017 Mar 8;7:43908.