PRGL493 是一种有效的选择性长链酰基辅酶A 合成酶 4 (ACSL4) 抑制剂。 PRGL493 阻断乳腺和前列腺细胞和动物模型中的细胞增殖和肿瘤生长。 PRGL493 用于癌症研究。
货号:ajcx23300
CAS:2479378-45-3
分子式:C25H21N7O2
分子量：451.5
溶解度:Chloroform: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PRGL493 is an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4).¹It inhibits formation of arachidonoyl-CoA (AA-CoA) from arachidonic acid in, as well as the proliferation and migration of, PC3 and MDA-MB-231 cancer cells when used at a concentration of 50 µM. PRGL493 (5 µM) reduces production of progesterone induced by 8-Br-cyclic AMP (8-Br-cAMP) in MA-10 Leydig tumor cells. It inhibits tumor growth in a PC3 mouse xenograft model when administered at a dose of 0.25 mg/kg.

1.Castillo, A.F., Orlando, U.D., Maloberti, P.M., et al.New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor growth, therapeutic resistance and steroidogenesisCell. Mol. Life Sci.(2020)