Squarunkin A hydrochloride 是一种有效的、选择性的 UNC119-cargo 相互作用抑制剂（抑制 UNC119A-myristoylated Src N-末端肽相互作用的 IC50 为 10 nM）。 Squarunkin A hydrochloride 干扰细胞中 Src 激酶的激活。
货号:ajcx27550
CAS:N/A
分子式:C25H32F3N5O4.HCl
分子量：560.01
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent inhibitor of UNC119 chaperone protein-cargo interaction (IC50 = 10 nM for inhibition of UNC119A - myristoylated Src N-terminal peptide interaction). Disrupts activation of Src kinase in vitro.

Mejuch et al (2017) Small-molecule inhibition of the UNC119-cargo interaction. Angew.Chem.Int.Ed. 56 6181 PMID:28471079