Pramlintide acetate 是一种人胰淀粉样多肽类似物。Pramlintide acetate 是一种抗糖尿病剂，也可用于肠癌的研究。
货号:ajcx36308
CAS:N/A
分子式:C173H273N51O55S2
分子量：4011.51
溶解度:H2O : 50 mg/mL (12.46 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Pramlintide acetate is a polypeptide analogue of human amylin. Pramlintide acetate, an antidiabetic agent, is antineoplastic in colorectal cancer[1].

Pramlintide inhibits the growth of HCT-116 and HT-29 in a dose-dependent manner, with higher efficacy against the latter (IC50s of 48.67 and 9.10 μg/mL, respectively)[1]. The addition of 5, 10, and 20 μg/mL of Pramlintide to HCT-116 and HT-29 with 5-fluorouracil, Oxaliplatin, or Irinotecan induces the antiproliferative effect synergistically[1].

[1]. Maha S Al-Keilani, et al. Pramlintide, an antidiabetic, is antineoplastic in colorectal cancer and synergizes with conventional chemotherapy. Clin Pharmacol. 2018 Mar 5;10:23-29.