FSG67 是一种甘油 3-磷酸酰基转移酶 (GPAT) 抑制剂，IC50 为 24 μM。
货号:ajcx39066
CAS:1158383-34-6
分子式:C16H25NO4S
分子量：327.44
溶解度:DMSO : 100 mg/mL (305.40 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

FSG67 is a glycerol 3-phosphate acyltransferase (GPAT) inhibitor with an IC50 of 24 μM[1].

FSG67 reduces GSK3β phosphorylation and signaling after acetaminophen overdose[1].FSG67 results in a dose-dependent increase in oxidative metabolism in mature adipocytes with an IC50 of 27.7 ± 4.4 μM[2].

[1]. Clemens MM, et al. The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling. Food Chem Toxicol. 2019 Mar;125:279-288. [2]. Reilly SM, et al. Catecholamines suppress fatty acid re-esterification and increase oxidation in white adipocytes via STAT3. Nat Metab. 2020 Jul;2(7):620-634.