An inhibitor of HDAC6
货号:ajcx24088
CAS:2484895-50-1
分子式:C25H21F3N6O3
分子量：510.5
溶解度:DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

NR-160 is an inhibitor of histone deacetylase 6 (HDAC6; IC₅₀= 0.03 µM).¹It is selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC₅₀s = 5.18, 2.26, 8.48, 55.4, and 14.7 µM, respectively). NR-160 is cytotoxic against a panel of seven cancer cell lines (IC₅₀s = 22.5-51.8 µM). It enhances cytotoxicity induced by bortezomib in HL-60 cells, as well as cytotoxicity induced by epirubicin or daunorubicin in CCRF-HSB-2 T cell acute lymphoblastic leukemia cells.

1.Reßing, N., SÖnnichsen, M., Osko, J.D., et al.Multicomponent synthesis, binding mode, and structure-activity relationship of selective histone deacetylase 6 (HDAC6) inhibitors with bifurcated capping groupsJ. Med. Chem.63(18)10339-10351(2020)