(E)-Akt inhibitor-IV ((E)-AKTIV) 是一种 PI3K-Akt 抑制剂，具有显著的细胞毒性。
货号:ajcx33096
CAS:959841-49-7
分子式:C31H27IN4S
分子量：614.54
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(E)-Akt inhibitor-IV ((E)-AKTIV) is a PI3K-Akt inhibitor, with potent cytotoxic[1].

(E)-Akt inhibitor-IV (compound 7) exhibits average GI20 of 0.04 μM on four cell lines (MDA-MB468 cells, MDA-MB231 cells, MCF7 cells and 184B5 cells)[1].(E)-Akt inhibitor-IV shows little effects on the growth of 184B5 non-cancer cells at the average GI20 doses[1].

[1]. Changkun Hu, et al. A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells. Eur J Med Chem. 2010 Feb;45(2):705-9.