ULK-101是一个有效的、选择性的ULK1抑制剂，其在体外测得的对ULK1和ULK2的IC50值分别为1.6nM和30nM。ULK-101抑制自噬，使癌细胞对营养胁迫敏感。
货号:ajcx13362
CAS:N/A
分子式:C22H16F4N4OS
分子量：460.45
溶解度:DMSO : 83.33 mg/mL (180.98 mM);H2O :< 0.1 mg/mL (insoluble)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ULK-101 is a potent and selective ULK1 inhibitor, with IC50 values of 1.6 nM and 30 nM for ULK1 and ULK2 in vitro, respectively. ULK-101 suppresses autophagy and sensitizes cancer cells to nutrient stress[1].

[1]. Martin KR, et al. A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress. iScience. 2018 Oct 26;8:74-84.