SX-682 是口服有效的 CXCR1 和 CXCR2 变构抑制剂。SX-682 可以阻断肿瘤髓系抑制细胞 (MDSCs) 募集并增强 T 细胞活化和抗肿瘤免疫。
货号:ajcx14456
CAS:1648843-04-2
分子式:C19H14BF4N3O4S
分子量：467.2
溶解度:DMSO: 250 mg/mL (535.10 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SX-682 is an orally bioavailable, potent allosteric inhibitor of CXCR1 and CXCR2. SX-682 can block tumor myeloid-derived suppressor cells (MDSCs) recruitment and enhance T cell activation and antitumor immunity[1].

[1]. Sun L, et al. Inhibiting myeloid-derived suppressor cell trafficking enhances T cell immunotherapy. JCI Insight. 2019 Apr 4;4(7).