NCC007 是一种双酪蛋白激酶 Iα (CKIα) 和 δ (CKIδ) 抑制剂，IC50 分别为 1.8 和 3.6 μM。NCC007 可用于哺乳动物昼夜节律的研究。
货号:ajcx14030
CAS:N/A
分子式:C22H28F3N7
分子量：447.5
溶解度:DMSO: 125 mg/mL (279.33 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

NCC007 is a dual casein kinase Iα (CKIα) and δ (CKIδ) inhibitor with IC50s of 1.8 and 3.6 μM, respectively. NCC007 can be used in research of modulating mammalian circadian rhythms[1]. CKIα|1.8 μM (IC50)|CKIδ|3.6 μM (IC50)

NCC007 (5-15 mM, infused into the lateral ventricle) controls circadian rhythms through CKI inhibition[1]. Animal Model: Adult C57BL/6J background male mice (8 weeks old)[1]

[1]. Lee JW, et al. Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ. J Med Chem. 2019 Feb 28;62(4):1989-1998.