GLP-26 是一种 HBV 衣壳组装调节剂 (CAM)，抑制 Hep AD38 系统中的 HBV DNA 复制 (IC50=3 nM)， 并在 1 μM 时使 cccDNA 降低>90％。GLP-26 破坏前基因组 RNA 的衣壳化，导致核衣壳解体，并减少 cccDNA 库。
货号:ajcx15354
CAS:2133017-36-2
分子式:C19H17F2N3O3
分子量：373.35
溶解度:DMSO: 125 mg/mL (334.81 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system (IC50=3 nM), and reduces cccDNA by >90% at 1 μM.GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools[1].

GLP-26 (0.7-1.7 μM; 3 days) reduces secreted HBeAg in HepNTCP-DL cells transfected with HBVwild type, with EC50 values of 0.7 μM[2]. Cell Viability Assay[2] Cell Line: HepNTCP-DL cells

[1]. Nijampatnam B, et al. Recent advances in the development of HBV capsid assembly modulators. Curr Opin Chem Biol. 2019 Jun;50:73-79.