VU6015929 是一种有效的，选择性的，口服活性的 DDR1/2 抑制剂，IC50 分别为 4.67 nM 和 7.39 nM。VU6015929 有效地阻止胶原蛋白诱导的 DDR1 激活和 IV 型胶原蛋白的产生。
货号:ajcx16376
CAS:N/A
分子式:C24H19F4N5O2
分子量：485.43
溶解度:DMSO: 250 mg/mL (515.01 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

VU6015929 is a potent, selective and orally active dual discoidin domain receptor 1/2 (DDR1/2) inhibitor with IC50s of 4.67 nM and 7.39 nM, respectively. VU6015929 potently blocks collagen-induced DDR1 activation and collagen-IV production[1].

[1]. Daniel E. Jeffries, et al. Discovery of VU6015929: A Selective Discoidin Domain Receptor 1/2 (DDR1/2) Inhibitor to Explore the Role of DDR1 in Antifibrotic Therapy. ACS Med. Chem. Lett. 2019.