HIF-2α-IN-4 是一种有效的 HIF-2α 翻译抑制剂，IC50 值为 5 μM。HIF-2α-IN-4 降低组成型和缺氧诱导的 HIF-2α 蛋白表达。HIF-2α-IN-4 将 5’UTR 铁响应元件与氧传感联系起来。
货号:ajcx36146
CAS:882268-69-1
分子式:C9H9N3O4S2
分子量：287.32
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5’UTR iron-responsive element to oxygen sensing[1].

HIF-2α-IN-4 (compound 76) (10 μM; 786-O cells) decreases HIF-2α mRNA translation in an mTOR-independent manner[1].HIF-2α-IN-4 decreases HIF-2α protein and HIF-2α target gene expression in normoxia and hypoxia[1].

[1]. Zimmer M, et al. Small-molecule inhibitors of HIF-2α translation link its 5’UTR iron-responsive element to oxygen sensing. Mol Cell. 2008;32(6):838-848.