SBI-425 是一种有效的，选择性和口服生物可利用的 TNAP 抑制剂。长期施用 SBI-425 可有效地达到并抑制脉管系统中的 TNAP，改善心血管参数和存活，并且其剂量不会引起骨的可检测变化。
货号:ajcx15476
CAS:1451272-71-1
分子式:C13H12ClN3O4S
分子量：341.77
溶解度:DMSO: 86.67 mg/mL (253.59 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SBI-425 is a potent, selective and oral bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor[1]. Long-term administration of SBI-425 effectively reaches and inhibits TNAP in the vasculature, improving cardiovascular parameters and survival at a dose that does not cause a detectable change in bone[2].

[1]. Pinkerton AB, et al. Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor. Bioorg Med Chem Lett. 2018 Jan 1;28(1):31-34. [2]. Sheen CR, et al. Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification. J Bone Miner Res. 2015 May;30(5):824-36.