CFTR corrector 6 是有效的囊性纤维化跨膜电导调节剂 (CFTR) 增强剂。CFTR corrector 6 有潜力用于囊性纤维化 (CF) 和其他 CFTR 相关疾病的研究。
货号:ajcx33864
CAS:2226970-01-8
分子式:C22H13F4N9
分子量：479.39
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CFTR corrector 6 is a potent potentiator of Cystic Fibrosis Transmembrane conductance Regulator (CFTR). CFTR corrector 6 has the potential for cystic fibrosis (CF) and other CFTR associated disorders research[1].

CFTR corrector 6 (Example 27) has EC50s of 1.25 nM and 1.27 nM for primary cystic fibrosis human bronchial epithelial (CF hBE) cells and fischer rat thyroid (FRT) cell lines[1].

[1]. Joseph Walter Strohbach, et al. Pyrrolopyrimidines as cftr potentiators. WO2018094137A1