CCR1antagonist9是一种有效的选择性CCR1拮抗剂，在钙通量实验中，CCR1antagonist9抑制CCR1的IC50为6.8nM。
货号:ajcx30346
CAS:1220026-26-5
分子式:C20H16FN5O3S
分子量：425.44
溶解度:DMSO: 83.33 mg/mL (195.87 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CCR1 antagonist 9 is a potent and selective CCR1 antagonist with an IC50?of?6.8 nM in calcium flux assay[1].

CCR1 antagonist 9 (Compound 19e) blocks the CCR1 chemotaxis of THP-1 cells with an IC50 of 28 nM. CCR1 antagonist 9 also blocks hERG with an IC50 of 30 μM[1].

[1]. Harcken C, et al. Identification of novel azaindazole CCR1 antagonist clinical candidates. Bioorg Med Chem Lett. 2019 Feb 1;29(3):441-448.