HN37 是有效且稳定的抗癫痫活性的化合物，其对 KCNQ2 的 EC50 值为 37 nM。
货号:ajcx38332
CAS:1821222-10-9
分子式:C20H21FN2O2
分子量：340.39
溶解度:DMSO : 50 mg/mL (146.89 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

HN37 as a potent and chemically stable antiepileptic drug candidate, with an EC50 of 37 nM for KCNQ2[1].

HN37 is a potent neuronal Kv7 activator with a subtype selectivity similar to RTG[1].

[1]. Yang-Ming Zhang, et al. Discovery of HN37 as a Potent and Chemically Stable Antiepileptic Drug Candidate. J Med Chem. 2021 May 13;64(9):5816-5837.