E3 ligase Ligand-Linker Conjugates 30 TFA 包含用于 E3 泛素连接酶 cereblon (CRBN) 配体和 linker。E3 ligase Ligand-Linker Conjugates 30 TFA 可通过 PROTAC 技术合成降解剂。
货号:ajcx13864
CAS:N/A
分子式:C23H29F3N4O9
分子量：562.49
溶解度:DMSO: 100 mg/mL (177.78 mM); Ethanol: 100 mg/mL (177.78 mM); H2O: 16.67 mg/mL (29.64 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

E3 ligase Ligand-Linker Conjugates 30 TFA incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 30 TFA can be used to design PROTAC degrader[1]. Cereblon

[1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62(2):448-466.