Sigma-1 receptor antagonist 2 是一种有效的选择性 sigma 1 受体 (σ1R) 拮抗剂，对 σ1 和 σ2 受体的 Ki 分别为 3.88 和 1288 nM。
货号:ajcx14224
CAS:1639220-15-7
分子式:C20H26ClN3O2
分子量：375.89
溶解度:DMSO: 86.67 mg/mL (230.57 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Sigma-1 receptor antagonist 2 is a potent and selective sigma 1 receptor (σ1 R) antagonist with Kis of 3.88 and 1288 nM for σ1 and σ2 receptor, respectively[1].

[1]. Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57(24):10404-23.