DFP00173 是一种有效的，选择性的 aquaporin-3 (AQP3) 抑制剂。DFP00173 抑制小鼠和人 AQP3，IC50 值为 ∼0.1-0.4 μM。DFP00173 对 AQP3 的选择性高于同源 AQP 亚型 AQP7 和 AQP9。
货号:ajcx15322
CAS:672286-03-2
分子式:C11H7Cl2N3O3S
分子量：332.16
溶解度:DMSO: 125 mg/mL (376.32 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

DFP00173 is a potent and selective aquaporin-3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with an IC50 of ∼0.1-0.4 μM. DFP00173 is selective for AQP3 over the homologous AQP isoforms AQP7 and AQP9[1].

DFP00173 inhibits the glycerol permeability of human erythrocytes with an IC50 of ~0.2 µM[1].

[1]. Sonntag Y, et al. Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors. J Biol Chem. 2019 May 3;294(18):7377-7387.