Lats-IN-1是一种高效的，ATP竞争性的Lats1和Lats2激酶抑制剂。Lats-IN-1能促进有丝分裂后哺乳动物组织的Yap依赖性增殖。
货号:ajcx31944
CAS:1424635-83-5
分子式:C18H14N4OS
分子量：334.39
溶解度:DMSO: 83.33 mg/mL (249.20 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Lats-IN-1 is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. Lats-IN-1 promotes Yap-dependent proliferation in postmitotic mammalian tissues[1].

The IC50 for Lats-IN-1 increases with the ATP concentration[1].Lats-IN-1 (10 μM; 24 hours) interferes with the ability of Lats kinases to phosphorylate Yap, with an EC50 of 510 nM[1].Lats-IN-1 causes Yap-dependent proliferation of murine supporting cells in the inner ear, murine cardiomyocytes, and human MÜller glia in retinal organoids[1].Lats-IN-1 fosters both the G1-S and G2-M checkpoint transitions and yields supporting cells capable of transdifferentiation[1]. Cell Proliferation Assay[1] Cell Line: MCF 10A cells

[1]. Nathaniel Kastan, et al. Small-molecule inhibition of Lats kinases promotes Yap-dependent proliferation in postmitotic mammalian tissues. bioRxiv 2020.02.11.944157.