ASLAN003 是一种具有口服活性，有效的 DHODH (人二氢乳清酸脱氢酶) 抑制剂，DHODH 是 AML (急性骨髓性白血病) 的新靶标。ASLAN003 具有抗肿瘤活性。
货号:ajcx14818
CAS:1035688-66-4
分子式:C19H14F2N2O3
分子量：356.32
溶解度:DMSO: 130 mg/mL (364.84 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ASLAN003 is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) which has the potential to be a first-in-class candidate in AML (Acute Myelogenous Leukemia). ASLAN003 has antitumor activity[1].

[1]. Marco L. Lolli, et al. Human Dihydroorotate Dehydrogenase (hDHODH) as a new target on Acute Myelogenous Leukemia (AML): Targeting Myeloid Differentiation using Potent and Innovative hDHODH Inhibitors. 23rd Swedish Conference on Macromolecular Structure and Function TÄllberg, 14-17 June 2019